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Recent research has discovered that a gene variant may predict naltrexone treatment success for alcoholism. About 50% of patients of Asian descent possess a particular mutation that makes them more likely to benefit from naltrexone, compared with about 20% of Caucasians and much less than 5% of African Americans, said lead study author Lara Ray, an assistant professor of psychology and director with the UCLA Addictions Laboratory. The findings are still available online ( inside the journal Neuropsychopharmacology and are published in the upcoming print edition in the journal. Using two separate drugs to lose weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight reduction and the people who go through it one should err on the side of caution and allow the FDA do its job and demand some research be done so the public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say anything to keep people on their medications. Researchers found that participants taking this drug to get a year, lost weight within one month and have kept the load off through the 56 weeks from the study. Contrave is often a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs that are made up of multiple active ingredient, which can make them more effective and safer. Combo-pilling will be the newest fad or also the newest to come under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular could be the fact that by right now there aren't any long term prescription diet pills that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and must not be taken in those with seizure disorders. The drug can also raise blood pressure level and heart rate, and must not be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must stop used in patients with uncontrolled high blood pressure levels, in addition to by you are not heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients to the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking. Acamprosate also functions eliminate the need to drink by reducing the the cravings for alcohol consumption. The major difference between Naltrexone and Acamprosate is the fact that Acamprosate isn't yet accessible in the United States. While it has been widely studied in Europe the precise chemical reason why it works remains to be unknown. It is thought that it disturbs receptors within the brain which process glutamate, which in effect alters the way in which ones body reacts to alcohol intake. Several of the European research has shown a lot of promise with Acamprosate in this some of the patients had a practically double rate of success for staying sober.